TargetNet
O14684
Prostaglandin E synthase
Function
Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).
Database Links
| Database | Links |
|---|---|
| UniProt | O14684 |
| PDB | 3DWW, 4AL0, 4AL1 |
| BioGrid | 114912 |
| BindingDB | O14684 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA33948 |
| KEGG | hsa:9536 |
| BioCyc | MetaCyc:HS07518-MONOMER |
| Entrez Gene (GeneID) | 9536 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9277 | 0.0055 |
| Accuracy | 0.8686 | 0.0083 |
| Sensitivity | 0.8723 | 0.0082 |
| Specificity | 0.865 | 0.0144 |
| BEDROC | 0.9485 | 0.0117 |
| MCC Threshold | 0.504 | N/A |
| MCC | 0.7485 | N/A |
| F-score Threshold | 0.462 | N/A |
| F-score | 0.8722 | N/A |