TargetNet
O00767
Acyl-CoA desaturase
Function
Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.
Database Links
| Database | Links |
|---|---|
| UniProt | O00767 |
| PDB | Not available |
| BioGrid | 112225 |
| BindingDB | O00767 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA34984 |
| KEGG | hsa:6319 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6319 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9736 | 0.0021 |
| Accuracy | 0.935 | 0.0044 |
| Sensitivity | 0.941 | 0.0039 |
| Specificity | 0.9278 | 0.0075 |
| BEDROC | 0.9988 | 0.0012 |
| MCC Threshold | 0.51 | N/A |
| MCC | 0.8814 | N/A |
| F-score Threshold | 0.51 | N/A |
| F-score | 0.9467 | N/A |