TargetNet
O00763
Acetyl-CoA carboxylase 2
Function
ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
Database Links
| Database | Links |
|---|---|
| UniProt | O00763 |
| PDB | 2DN8, 2HJW, 2KCC, 3FF6, 3GID, 3GLK, 3JRW, 3JRX, 3TDC, 4HQ6 |
| BioGrid | 106550 |
| BindingDB | O00763 |
| DrugBank | DB00121 |
| Guide to PHARMACOLOGY | 1264 |
| PharmGKB | PA24422 |
| KEGG | hsa:32 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 32 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9916 | 0.005 |
| Accuracy | 0.9677 | 0.0051 |
| Sensitivity | 0.966 | 0.0076 |
| Specificity | 0.9698 | 0.0035 |
| BEDROC | 1 | 6.5407 × 10-6 |
| MCC Threshold | 0.454 | N/A |
| MCC | 0.9271 | N/A |
| F-score Threshold | 0.448 | N/A |
| F-score | 0.9669 | N/A |