TargetNet
O00748
Cocaine esterase
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Database Links
| Database | Links |
|---|---|
| UniProt | O00748 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | O00748 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA377 |
| KEGG | hsa:8824 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 8824 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9253 | 0.0095 |
| Accuracy | 0.86 | 0.0109 |
| Sensitivity | 0.8677 | 0.0177 |
| Specificity | 0.8531 | 0.0117 |
| BEDROC | 0.9814 | 0.0094 |
| MCC Threshold | 0.588 | N/A |
| MCC | 0.7383 | N/A |
| F-score Threshold | 0.384 | N/A |
| F-score | 0.8664 | N/A |