TargetNet
O00519
Fatty-acid amide hydrolase 1
Function
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Database Links
| Database | Links |
|---|---|
| UniProt | O00519 |
| PDB | Not available |
| BioGrid | 108464 |
| BindingDB | O00519 |
| DrugBank | DB00818, DB00599 |
| Guide to PHARMACOLOGY | 1400 |
| PharmGKB | PA27955 |
| KEGG | hsa:2166 |
| BioCyc | MetaCyc:HS04139-MONOMER |
| Entrez Gene (GeneID) | 2166 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9442 | 0.0027 |
| Accuracy | 0.8834 | 0.0034 |
| Sensitivity | 0.8769 | 0.0065 |
| Specificity | 0.89 | 0.0059 |
| BEDROC | 0.9913 | 0.0046 |
| MCC Threshold | 0.482 | N/A |
| MCC | 0.7629 | N/A |
| F-score Threshold | 0.342 | N/A |
| F-score | 0.8865 | N/A |