TargetNet
O00408
cGMP-dependent 3',5'-cyclic phosphodiesterase
Function
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.
Database Links
| Database | Links |
|---|---|
| UniProt | O00408 |
| PDB | 1Z1L, 3IBJ, 3ITM, 3ITU, 4HTX, 4HTZ, 4JIB |
| BioGrid | 111164 |
| BindingDB | O00408 |
| DrugBank | DB00203, DB00605 |
| Guide to PHARMACOLOGY | 1297 |
| PharmGKB | PA33125 |
| KEGG | hsa:5138 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5138 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9745 | 0.0025 |
| Accuracy | 0.9242 | 0.0076 |
| Sensitivity | 0.8902 | 0.0147 |
| Specificity | 0.9622 | 0.0178 |
| BEDROC | 0.9999 | 8.2719 × 10-6 |
| MCC Threshold | 0.582 | N/A |
| MCC | 0.8417 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.9176 | N/A |