TargetNet
O00311
Cell division cycle 7-related protein kinase
Function
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.
Database Links
| Database | Links |
|---|---|
| UniProt | O00311 |
| PDB | 4F99, 4F9A, 4F9B, 4F9C |
| BioGrid | 113914 |
| BindingDB | O00311 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA26272 |
| KEGG | hsa:8317 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 8317 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9796 | 0.0031 |
| Accuracy | 0.9346 | 0.0053 |
| Sensitivity | 0.9443 | 0.0074 |
| Specificity | 0.9241 | 0.007 |
| BEDROC | 0.9993 | 7.463 × 10-4 |
| MCC Threshold | 0.388 | N/A |
| MCC | 0.8903 | N/A |
| F-score Threshold | 0.388 | N/A |
| F-score | 0.9482 | N/A |